Search results for "Hystaminergic system"

High turnover rate of central histaminergic system in patients with Down syndrome and Alzheimer disease

2013

HIGH TURNOVER RATE OF CENTRAL HISTAMINERGIC SYSTEM IN PATIENTS WITH DOWN SYNDROME AND ALZHEIMER DISEASE Maria Concetta Gueli Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNEC), Università degli Studi di Palermo It is well confirmed that a strong relationship exists between Down’s syndrome (DS) and Alzheimer’s disease (AD). Neurochemical investigations reported that many central neurotransmitter systems are similarly affected in aging Down and in Alzheimer patients, respectively. Airaksinem et al. (1) found numerous neurofibrillary tangles in the tuberomammillary area of the hypothalamus, where cell bodies of histaminergic neurons are located. While Mazurkiewicz-Kwilec…